Pravastatin, lovastatin, and simvastatin are indicated for patients with documented CAD to slow progression of the disease. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Drug cards 15 Terms. Davis's Drug Guide for Rehabilitation Professionals, https://fadavispt.mhmedical.com/content.aspx?bookid=1873§ionid=139025844. Most of an absorbed dose is extracted from the blood on it's first pass … Assess signs and symptoms of CHF (dyspnea, rales/crackles, peripheral edema, jugular venous distention, exercise intolerance) to help document whether drug therapy is effective in reducing these … Considerations for Treatment With Simvastatin (Zocor) There are several considerations you must discuss with your primary care provider before beginning treatment with simvastatin (Zocor). - In the case of rhabdomyolysis with increased muscle tenderness and creatine phosphokinase, therapy should be discontinued. Search. Therapeutic Effects: Lowering of total and LDL cholesterol and triglycerides. Peak plasma concentrations are achieved in 1 to 1.5 hours. HMG-CoA reductase inhibitors increase HDL cholesterol, and decrease LDL cholesterol, and total cholesterol synthesis. Simvastatin may also be used to decrease the amount of cholesterol and other fatty substances in the blood in children and teenagers 10 to 17 years of age who have familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally). Restricted dosing . Mechanism of Action. Timing: Give drug in the evening. Thus, atorvastatin at 10-5M, elicited the same effects on MFB-turnover as previously described in vivo. Lipid determinations should be performed after 4 weeks of therapy and periodically thereafter. Secondary prevention of myocardial infarction, coronary revascularization, stroke, and cardiovascular mortality in patients with clinically evident coronary heart disease. https://fadavispt.mhmedical.com/content.aspx?bookid=1873§ionid=139025844. Amount absorbed range between 30% to 90%. Statins are medications used to help lower cholesterol levels. GENERIC NAME: Venlafaxine BRAND NAME: Effexor Use extreme caution. The mean percent difference at Week 6 between the pooled ezetimibe coadministered with simvastatin and the pooled … The recommended dose range of simvastatin is 10 mg to 40 mg, and it is administered once daily in the evening with or without food. simvastatin is a topic covered in the Davis's Drug Guide.. To view the entire topic, please sign in or purchase a subscription.. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), … - Medication should be stored in a closed container in a cool, dry, dark place, out of the reach of children. – Fentanyl interferes with respiratory function and pupil reaction, both of which are essential parts of neurological assessment. X. Nursing considerations: – Repeated intraoperative doses can cause respiratory depression to persist into the postoperative period. The following are the general nursing interventions and considerations when administering colloid IV solutions: Assess allergy history. Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. He is 84 years old, lives by himself, and his youngest daughter Bonnie lives just down the street. Nursing considerations: – Repeated intraoperative doses can cause respiratory depression to persist into the postoperative period. Statins are administered orally. Therapeutic: lipid-lowering agents. Monitor other CNS symptoms such as confusion, hallucinations, and headache. Inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase; similar in action to lovastatin but more potent. Simvastatin nursing responsibilities. Susan Waterbury is a family NP in private practice (Florida) and an online nursing instructor for the University of Phoenix, Phoenix, Ariz. The authors and planners have disclosed no financial relationships related to this article. Simvastatin is a prescription drug. Counsel patients about additional interventions to help control lipid disorders and improve cardiovascular health, including dietary modification, regular exercise, moderation of alcohol consumption, and smoking cessation. - Evaluate therapeutic response: decreased constipation or blood ammonia level. - Perform liver function tests in first year of treatment. MS: RHABDOMYOLYSIS, arthralgia, myalgia, myositis. This is because statins can affect your liver, and this is more likely to cause serious problems if you already have a severely damaged liver. Derm: rashes, pruritus. - Nurses should refer to manufacturer’s summary of product characteristics and to appropriate local guidelines. Simvastatin is a lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Simvastatin oral tablet is available as the brand-name drug Zocor. This div only appears when the trigger link is hovered over. Here are important nursing considerations when administering bile acid sequestrants: ... Pravastatin, lovastatin, and simvastatin are indicated for patients with documented CAD to slow progression of the disease. Therapeutic use. • Assess blood pressure and pulse. Simvastatin is a prescription drug. Therapy usually is initiated with 10 or 20 mg daily, but individuals who have a high risk of heart disease can be started on 40 mg daily. Withhold drug and notify physician if CPK levels are markedly elevated (10xULN) or if myopathy is diagnosed or suspected. 53. Rosuvastatin is a potent inhibitor of HMG-CoA reductase, an enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, an early and rate-limiting step in cholesterol biosynthesis. 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