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Solubility and dissolution are different concepts, but are related. The saturation solubility was measured in water or in the presence of surfactant at 32 °C with a Sirius ® inForm based on in situ UV–vis spectroscopy. 1 0 obj
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2.84 EXPERIMENTAL CONSIDERATIONS 85 Overall, the API sample should be dissolved/suspended in the buffer, then separated by 86 appropriate methods and, in the end, its concentration should be determined in the liquid 87 phase/supernatant. stream Saturated solubility study The data for the saturated solubility study is provided in Fig. Beyond this saturation concentration, a … endobj
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