Linoleic acid, another anti-SARS-CoV-2 weapon. New York, United States, Tue, 10 Nov 2020 08:19:34 / Comserve Inc. / -- … Linoleic acid is a polyunsaturated omega-6 fatty acid. The current epidemic of COVID-19 (coronavirus) has been declared by WHO as a global epidemic. All these infections could be traced to zoonotic transmission. Linoleic acid (LA) is a free fatty acid, which is needed for many cellular functions and cannot be produced by the human body. This COVID-19 epidemic is somewhat similar to the previous severe acute respiratory syndrome (SARS-CoV-2 or SARS; 2002-2003) and Middle East respiratory syndrome (MERS; 2012-ongoing) outbreaks. The effects of linoleic acid on the human body are largely dependent on genes, a new study shows. Both alkene groups are cis. Linoleic acid is an organic compound with the formula HO 2 C(CH 2) 7 CH=CHCH 2 CH=CH(CH 2) 3 CH 3. All 3 viral infections … It is a fatty acid sometimes denoted 18:2 (n-6) or 18:2 cis-9,12. Using a powerful imaging technique called electron cryo-microscopy, they studied the molecular structure of the virus and found the pocket, with a small molecule, linoleic acid … The aforementioned viral-host interaction, resulting in a lower "affinity" of SARS-CoV-2 towards the ACE2 … Dear Editor, A nice and elegant article recently published in Science (1) reports the interaction dynamics occurring between the host cell receptor binding domain (RBD) of SARS-CoV-2 spike (S) protein and linoleic acid (LA). However, the mechanisms underlying the anti-inflammatory effects of FLR and its major constituent, linoleic acid (LA), are still largely unknown. Linoleic acid is an essential fatty acid. A linoleate is a salt or ester of this acid. The MarketWatch News Department was not involved in the creation of this content. The team discovered that buried deep within the spikes that the SARS CoV-2 protein uses to latch onto the inside of people’s bodies was a small molecule called linoleic acid. In this study, we investigated the anti-inflammatory effects of FLR and LA on lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 murine macrophages.

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